When Sulfur becomes the real bottleneck
Sulfur starts to matter when ammunition, explosives, or combat preparation become repeatable instead of occasional. If every boss run or dangerous route requires another restock, stop treating Sulfur as a casual pickup and plan a route with storage space, return timing, and enough combat readiness to avoid losing the run.
How to combine Sulfur with other routes
A good Sulfur trip should often overlap with mining, oil-rig preparation, or late-game combat supply planning. Check whether Ore, Coal, Flame Organ, or Ancient progression materials are also part of the next objective, then farm in a way that reduces travel loops instead of solving only one missing stack.